Recent Updates on Narcolepsy and Hypersomnia
نویسندگان
چکیده
منابع مشابه
Causes of Hypersomnia – Narcolepsy
Volitional sleep deprivation and obstructive sleep apnea are the most common causes of hypersomnia. The remaining causes are primarily due to p r imary cen t r a l ne rvous sys t em abnormalities, the most common of which is narcolepsy, a primary disorder of the neural control of wakefulness and sleep.
متن کاملIgG Abnormality in Narcolepsy and Idiopathic Hypersomnia
BACKGROUND A close association between narcolepsy and the Human Leukocyte Antigen (HLA)-DQB1*0602 allele suggests the involvement of the immune system, or possibly an autoimmune process. We investigated serum IgG levels in narcolepsy. METHODOLOGY/PRINCIPAL FINDINGS We measured the serum total IgG levels in 159 Japanese narcolepsy-cataplexy patients positive for the HLA-DQB1*0602 allele, 28 id...
متن کاملSuccessful treatment of idiopathic hypersomnia and narcolepsy with modafinil.
1. Modafinil, a putative central alpha 1 adrenergic agonist, was tested in idiopathic hypersomnia and narcolepsy. 2. Sleep attacks and drowsiness were significantly decreased in 83% of 18 hypersomniac subjects and 71% of 24 narcoleptics. 3. When cataplectic episodes were not totally suppressed the association of a low dose of Clomipramine was successful in improving them. 4. Modafinil, used for...
متن کاملHypocretin (orexin) deficiency in narcolepsy and primary hypersomnia.
The discovery that hypocretins are involved in narcolepsy, a disorder associated with excessive daytime sleepiness, cataplexy, and unusually rapid transitions to rapid eye movement sleep, opens a new field of investigation in the area of disorders of sleep and activation. Hypocretin-1 (hcrt-1) and hypocretin-2 (hcrt-2) (also called orexin-A and orexin-B) are newly discovered neuropeptides proce...
متن کاملUsefulness of genetic characterization of narcolepsy and hypersomnia on phenotype definition: a study in Portuguese patients.
INTRODUCTION The determination of human leukocyte antigen (HLA) class II genotype is widely used to confirm the diagnosis of narcolepsy with or without cataplexy. The HLA genotyping is reliable, easy to perform and reassures the clinician. It is also less invasive than other methodologies and is in accordance with the autoimmune hypothesis for the origin of narcolepsy. AIM. To assess the useful...
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ژورنال
عنوان ژورنال: Journal of Korean Neuropsychiatric Association
سال: 2020
ISSN: 1015-4817,2289-0963
DOI: 10.4306/jknpa.2020.59.1.25